The application relates to inhibitors of Trk kinases useful in the treatment of Trk kinase associated diseases and disorders, having the Formula:,wherein A, L, X, X1, and Y are described herein.本案關於Trk激酶的抑制劑,其有用於治療與Trk激酶相關之疾病或病症,具有下式:,其中A、L、X、X1、及Y如本文中所述。