It describes the drug composition of a diagnostician of glutamate 5 (mGlu5) metabolite receptors or pharmaceutically acceptable salts, which contain active therapeutic complexes as well as nonionic and ionic polymers, Polymer and filler in the form of matrix pellet,Matrix plate or sphere, its composition provides a brief introduction of release and ldqe； in test tube and rdqoe； independent of pH value, it can reach 70% in 1 hour, 85% in 4 hours and 80% NMT in 8 hours, all of which are helpful to deal with the disorder of harmful substances, For example, anti therapeutic depression (TRD) and fragile x-retrification 1: drug ingredients of layered pellet,It includes: (a) an inert core； (b) a layer containing a formula compound (1), wherein a or E is n and C is C； R1 is halogen or cyanogen； R2 is lower tar； R3 is arilo or heterosexual, and can be replaced by one, two or three alternatives selected from halogen or lower tar, Low oxygen, epoxy, low halogen, low halogen, low halogen, cyanogen and NR rsqoe； R rsqoe； rsqoe；,or by 1-morpholinyl, 1-pyrrolidinyl, optionally substituted by (CH2) mOR, piperidinyl, optionally substituted by (CH2) mOR, 1,1-dioxo-thiomorpholinyl or piperazinyl, optionally substituted by lower alkyl or (CH2) m-cycloalkyl ； R is hydrogen, lower alkyl or (CH2) m-cycloalkyl； R and R are independently hydrogen, lower alkyl, (CH2) m-cycloalkyl or (CH2) nOR； m is the number 0 or 1； n is the number 1 or 2； and R4 is CHF2, CF3, C (O) H or CH2R5, wherein R5 is hydrogen, OH, C1-6 alkyl or C3-12 cycloalkyl； and its pharmaceutically acceptable salts；(c) A controlled release layer containing a speed controlled polymer； and (d) a layer containing a polymer dissolved in accordance with pH: the components required in Item 1, including: (a) an inert core； (b) a layer containing a formulated compound (1)；(c) An optional separation layer； (d) a controlled release layer containing a speed controlled polymer； (E) a layer containing a polymer dissolved according to pH；
