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FORMULATION DE MÉDICAMENT À LIBÉRATION RETARDÉE
专利权人:
Tillotts Pharma AG
发明人:
申请号:
EP17157257.1
公开号:
EP3187171A1
申请日:
2012.04.30
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a non-ionic polymer as a third polymeric material which is soluble in intestinal fluid, together with a buffer agent and/or a base.
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