YU, SUNG LIANG,俞松良,俞松良,HO, BING CHING,何炳庆,何炳慶,YANG, PAN CHYR,杨泮池,楊泮池
申请号：
TW103140735
公开号：
TW201610152A
申请日:
2014.11.24
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention found that host miRNAs might be involved in Picornavirus pathogenesis through suppression of type I IFNs induction and could act as candidates for developing antiviral therapy. Thus, the invention suggests enterovirus-induced miR-146a facilitates viral pathogenesis by suppressing IFN production and provide a clue to develop the preventive and therapeutic strategies for enterovirus infections.本發明發現宿主miRNA可能經由抑制I型IFN誘發而涉及小核醣核酸病毒發病機制,且可作為用於研發抗病毒療法之候選物。因此,本發明提出腸病毒誘發之miR-146a藉由抑制IFN產生而促成病毒發病機制,且提供一條研發用於腸病毒感染之預防性及治療性策略的線索。
