Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.本文所揭示者係核苷酸類似物、合成核苷酸類似物的方法、及用一或多種核苷酸類似物來治療疾病及/或病況(諸如小核糖核酸病毒科(Picornaviridae)及/或黃病毒科(Flaviviridae)病毒感染)的方法。