The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of Tau protein expression is beneficial for the treatment of certain medical disorders,e.g., a neurological disorder.本發明係關於寡聚物化合物(寡聚物),其靶向細胞中之Tau mRNA,導致Tau蛋白之表現減少。Tau蛋白表現之減少對某些醫學病症(例如神經病症)之治療有益。