ЛАУРИ Дэвид Дж.,БАГИ Джозеф Дж.,МОДИ Тарак Д.,ВЕРНЕР Эрик Дж.,ПУРРО Норберт,БАЛАСУБРАМАНИАН Срирам,КЛООС Йоанна,ДЕПИЛ Стефан
申请号：
RU2014111069
公开号：
RU2014111069A
申请日:
2011.09.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A pharmaceutical composition comprising: (a) Compound 1: or a pharmaceutically acceptable salt thereof (b) bendamustine, or a pharmaceutically acceptable ester, salt or solvate thereof and (c) at least one pharmaceutically acceptable auxiliary veschestvo.2. A pharmaceutical composition according to Claim. 1 which is a pharmaceutical composition vysvobozhdeniem.3 controlled. A pharmaceutical composition according to claim 2, which completely releases the active ingredient (s): (i) at a constant rate over a period of about 6 hours to about 10 hours after oral administration to humans. (Ii) at a decreasing rate over a period from about 6 hours to about 10 hours after oral administration to humans or (iii) in the form of pulses during a period from about 6 hours to about 10 hours after oral administration cheloveku.4. A pharmaceutical composition according to claim. 2, which releases less than about 10% of the active ingredient in the stomach after oral administration cheloveku.5. A pharmaceutical composition according to Claim. 1, which is suitable for separate, sequential and / or simultaneous administration of bendamustine and Compound 1.6. A pharmaceutical composition according to Claim. 1, which is in a solid dosage forme.7. A pharmaceutical composition according to Claim. 1, which compound is an inhibitor of one HDAC.8. A pharmaceutical composition according to claim. 7, in which the HCl salt of Compound 1 inhibits HDAC.9. The combination of bendamustine, or a pharmaceutically acceptable ester, salt or solvate, and HDAC inhibitor, wherein the HDAC inhibitor is Compound 1: or a pharmaceutically acceptable1. Фармацевтическая композиция, содержащая:(a) Соединение 1:или его фармацевтически приемлемую соль(b) бендамустин или его фармацевтически приемлемый сложный эфир, соль или сольват и(c) по меньшей мере, одно фармацевтически приемлемое вспомогательное вещество.2. Фармацевтическая композиция по п. 1, которая представляет собой фармацевтическую композицию с контрол
