Certain compounds of the present are especially useful for treating pain.Claim 1: a compound characterized by the formula (1) or a pharmaceutically acceptable Salt or solvate thereof, where Cy is a carboc u00edclico FUSED Ring 3 to 8 members or partially saturated unsaturated； Oh； r u00b9 is Hydrogen, cyano, carboxy, Halo, or - C (= o) nh u2082 or rent； at Lquenilo, alquinilo, alkoxy, or alqueniloxi, alquiniloxi,Any of which is optionally substituted with 1, 2 or 3 substituents each independently selected from the group consisting of Hydroxy, Halo, haloalquilo alquilamino, dialquilamino, amino, carboxy, alcoxicarbonilo, aryl, heteroaryl, heterocycle, cycloalkyl, and cicloalque Nile, where such Heterocyclic cycloalkyl, aryl, heteroaryl,,And cicloalquenilo are optionally substituted with 1, 2 or 3 groups r u2075 independently selected； or - or PG, PG is a hydroxyl Protecting Group； R u00b2 is Hydrogen or carboxamido (a) or (b) alquenilo, alkyl, cycloalkyl, alquinilo, cicloalquenilo heterocycle aryl, heteroaryl (,,, Cicloalquil) alkyl (cicloalquenil) alkyl (alkyl, arylalkyl heterocycle), heteroarilalquilo,Alquilcarbonilo, alcoxicarbonilo (arilalcoxi), carbonyl, carbonyl or (heteroarilalcoxi), either of which is optionally substituted with 1, 2 or 3 substituents each independently selected from the group consisting of alkyl, Hydroxy, amino, Halo, haloalquilo, alquilamino, day Lquilamino, carboxy, alkoxy, alcoxicarbonilo heteroaryl, aryl, Heterocyclic cycloalkyl,,,And cicloalquenilo, where these aryl, heteroaryl, Heterocycles, and cicloalquenilo are optionally substituted cycloalkyl, with 1, 2 or 3 groups r u2075 independently selected； r u00b3 is Hydrogen, Oh, or Halo, or alquilamino, alkoxy, or dialquilamino, either of which is opcionalme Nte replaced with 1, 2 or 3 substituents.Each independently selected from the group consisting of Hydroxy, amino, Halo, haloalquilo, alquilamino, dialquilamino, carboxy, alkoxy, alcoxicarbonilo, aryl, heteroaryl, and cicloalquenilo he
