FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
发明人:
SOENGAS GONZALEZ, MARIA SOLEDAD,TORMO CARULLA, DAMIA
申请号：
NZ59779310
公开号：
NZ597793A
申请日:
2010.07.05
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
597793 PROCESS FOR THE IDENTIFICATION OF COMPOUNDS FOR TREATING CANCER Provided is a process for the identification of compounds to be used as therapeutic agents for treating cancer comprising the steps of: a) Contacting the candidate compound with a cancer cell culture, or cancer cell line derived from cancer cells； b) Determining the level of activation of a family helicase MDA-5 or the level of NOXA expression, in combination with the determination of the induction of autophagy in cancer cells or in a cell line derived from cancer cells； c) Comparing the data obtained in step b) with those observed in control of the same cells treated similarly, but in the absence of the candidate compound； d) Selecting the compounds which have given rise to a significant increase in the parameter or parameters determined in step b) in comparison with the control. Further provided is an autophagy inducing compound by way of the length of the at least 1000 nucleotides long polyinosine-polycytidylic acid (pIC) combined with polyethyleneimine (PEI).
