Nicolas Lachance;Chun Sing Li;Jean-Philippe Leclerc;Oscar Miguel Moradei
发明人:
Nicolas Lachance,Jean-Philippe Leclerc,Chun Sing Li,Oscar Miguel Moradei
申请号：
US13148985
公开号：
US09168248B2
申请日:
2010.02.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis； obesity； diabetes； neurological disease； metabolic syndrome； insulin resistance； and liver steatosis.
