Jean-Philippe Leclerc,Chun-Sing Li,Oscar Miguel Moradei
申请号：
US13383446
公开号：
US08383643B2
申请日:
2010.07.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis obesity diabetes neurological disease metabolic syndrome insulin resistance and liver steatosis.
