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AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
专利权人:
MERCK CANADA INC.
发明人:
申请号:
EP07845603.5
公开号:
EP2099793B1
申请日:
2007.11.28
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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