Multispecific antibodies (e.g., bispecific antibodies) that bind to HIV gp120 and CD3 are disclosed. Also disclosed are methods of using such antibodies to treat or prevent HIV infection.本文揭示結合至HIV gp120及CD3之多特異性抗體(例如雙特異性抗體)。本文亦揭示使用此等抗體以治療或預防HIV感染之方法。