the present invention relates to a method for creating inhibitors bind \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 gp120 hiv with \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c cd4 or \u0438\u043d\u0442\u0435\u0433\u0440\u0438\u043d\u043e\u043c \u03b14\u03b27 (a4b7).the method includes a molecular modeling compounds, in which the \u043c\u043e\u0434\u0435\u043b\u0438\u0440\u0443\u0435\u043c\u043e\u0435 compound virtually interacts at least two amino acid supplemented diets available the kami of the six motivations within the three-dimensional structure of gp120 hiv or inside \u043f\u0435\u043f\u0442\u0438\u0434\u043e\u043c\u0438\u043c\u0435\u0442\u0438\u043a\u0430 reflecting the 3-d structure of gp120 hiv.such interaction is characterized by the distance between the atoms, nor less 8\u00c5 and these motives include consistency DIISLWDQSLKPCVKLT, NVSTVQCTHGIRPVVSTQLLLNG SLAE, SGGDPEIVMHSFNCGGEFFYCN, CPKISFEP, FRPGGGDMRDNWRSELYKYKVV and css or their variants.the invention also relates to a method of searching for inhibitors of hiv gp120 with cd4 or \u0438\u043d\u0442\u0435\u0433\u0440\u0438\u043d\u043e\u043c a4b7, compounds that slow down the binding to cd4 and hiv gp120 if \u0438\u043d\u0442\u0435\u0433\u0440\u0438\u043d\u043e\u043c a4b7, method of reducing heat of the tunnel inside gp120 hiv, to search for compounds used for the prevention or treatment of hiv infection or relevant \u043d\u043d\u044b\u0445 with hiv disease, and pharmaceutical compositionswith any of these compounds or inhibitors. the invention also relates to the use of the tunnel inside gp120.Настоящее изобретение относится к разработке метода создания ингибитора связывания гликопротеина gp120 ВИЧ с рецептором CD4 или интегрином α4β7 (a4b7). Метод включает молекулярное моделирование соединения, при котором моделируемое соединение виртуально взаимодействует как минимум с двумя аминокислотными остатками из шести мотивов внутри трехмерной структуры gp120
