The present invention includes a method to produce immune-active milk products from raw milk. The method includes the steps of separating a raw milk composition into a nonfat milk fraction and a fat fraction, followed by UV-C pasteurization of the nonfat milk fraction to yield the immune-active milk product. Optionally, a composition comprising milk fat globule membrane components is added to the nonfat milk fraction either prior to or subsequent to the UV-C pasteurization step. Optionally, the nonfat milk fraction is treated with lactase to hydrolyze the lactose. The method can also optionally include a step of low-temperature drying of the immune-active milk composition, or alternatively ultrafiltration and/or diafiltration can be used to produce a milk protein concentrate as the immune-active milk products. The immune-active milk products obtained by the methods of the invention can be used to reduce, prevent or treat immune dysfunctions.
