PROCÉDÉ DE PRÉPARATION D'UN COMPRIMÉ DE FLOTTATION AVEC UNE ACTIVITÉ PROLONGÉE DE SUBSTANCES THÉRAPEUTIQUES AGISSANT SUR UNE MEMBRANE MUQUEUSE DE L'ESTOMAC ET UNE COMPOSITION PHARMACEUTIQUE
Uniwersytet Medyczny Im. Piastów Slaskich We Wroclawiu
发明人:
申请号：
EP15170443.4
公开号：
EP2952175A1
申请日:
2015.06.03
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The object of the present invention is a method of manufacturing a floating tablet with extended interaction of therapeutic substances with stomach mucosa, comprising the steps of weighing therapeutic substances, sugar alcohols, acid polymers and anti-adhesion and lubricating substances, mixing them together, pouring into the tablet press hopper and pressing tablets having the diameter of 4 to 28 mm, using pressing force of 50 to 100,000, the therapeutic substance being preferably a compound selected from the group containing: pioglitazone hydrochloride, cephalexin, potassium losartan, captopril, diltiazem, chlorhexidine hydrochloride, and the acid polymer constitutes 0.5% - 94.9%wt. of the mixture, sugar alcohols constitute 5.0 - 99.4%wt. of the mixture, anti-adhesive and lubricating substances constitute 0.1% - 0.5%wt. of the mixture, The object of the present invention is also a pharmaceutic composition containing a therapeutic substance, sugar alcohols, acidic polymers of organic acids, and anti-adhesive and lubricating substances, the therapeutic substance being preferably a compound selected from the group containing: pioglitazone hydrochloride, cephalexin, potassium losartan, captopril, diltiazem, and the acid polymer constitutes 0.5% - 94.9%wt. of the composition, sugar alcohols constitute 5.0 - 99.4%wt. of the composition, anti-adhesive and lubricating substances constitute 0.1%-1.5%wt. of the composition,
