IGNYTA, INC.;IGNYTA; INC.;CANCER RESEARCH TECHNOLOGY LIMITED
发明人:
BRUCE DORSEY,BENJAMIN J. DUGAN,KATHERINE M. FOWLER,ROBERT L. HUDKINS,EUGEN F. MESAROS,NATHANIEL JT MONCK,EMMA L. MORRIS,IKEOLUWA OLOWOYE,GREGORY R. OTT,GREGOIRE A. PAVE,JONATHAN R. A. ROFFEY,CHRISTELL
申请号：
ARP150100873
公开号：
AR099831A1
申请日:
2015.03.25
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
The application provides a compound of formula (1) and / or a salt thereof, wherein R1,G and X are defined in this report. A formula compound (1) and / or its salts have inhibitory aPKC activity and may be used in the treatment of diffuse disorders. The composition of the compound and / or salt of formula (1) is also listed. 1. Claim 1: a compound of formula (1) and / or formula salt, characterized in that G is a group of formula (2),(3) (4)X is selected from the halogen group, - CN, - C (= O) r8322；-C (3DO) OR-C (= O) No. 830808； R 2 831222；-C (3DO) C (3DO) R-830888； 831222；-8308； 830808； 83012；-N = No. 831222；-830888； 831222；-No. 8308； (= O) No. 831222；-8308； C (= O) C (= O) r8322；-83088c (= O) or 821222；-No. 830808 (= O) C (= O) No. 831222；-No. 8328； (= O) No. 830808； - No. 8322；-No. 8308； (= O) No. 8308； = C (= O) No. 8322；-No. 8328； (= O) No. 8308； = C (= O) No. 831222；-No. 8328； (= O) C (= O) No. 8308； - No. 8322；- 8308th；]- 8308th；]-831222,-OC (3DO) R-OC (3DO) NR R-OC (3DO) OR-OS (3DO) R-OS (3DO) R-OS (3DO) OR-OS (= O) 8322； - No. 830808； - No. 8322；-S (3DO) R-S (= O) 8322； No. 830808； No. 8322；y -S (3DO) NR RO x selected from apartment group c8321； apartment group 832031；C₂₋₆ alkenyl,1. C 83228331 asphalt；arilo Carilalquilo CC₃₋₁₁ cycloalkyl,C₄₋₁₇ cycloalkylalkyl,1.3-15 non cyclopentanediol, 4-21 non cyclopentanediol, 5-15 non cyclopentanediol and 6-21 non cyclopentanediol, each of which can be replaced by 1-10 r18313；R¹ is selected from the group consisting of C₃₋₁₁ cycloalkyl optionally substituted with 1-10 R¹⁹,C₁₋₆ haloalkyl,e. Asphalt-oc83218c331266；R2,R3,R830808,R83099,1. Each substance is selected from the group consisting of H, halogen, - CN, - C (= O) R 83044；-C (3DO) OR-C (3DO) NR R-C (3DO) C (3DO) R-C (= No. 83099) r * 830404；-C (= NR²⁵) NR²²R²³,-C (3DNOH) NR R-C (3DNOR) R-C (= NNR²²R²³) R²⁰,-C (3DNNR C (3DO) R) R-C (3DNNR C (3DO) OR) R-C (3DS) NR R-NC, -NO₂,-3 number-830888, 3-N = No. 830808,-830888； 8310；-No. 8308； (= O) No. 830404；,-8308； C (
