OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5-TERMINAL THEREOF

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专利权人:

发明人:

Fumikazu SHINOHARA,Asana MAKINO,Junichiro YAMAMOTO,Takahiro NAKAJIMA,Taiji OASHI,Michihiko SUZUKI,Jun-ichi SAITO,Tomoyuki NISHIKAWA,Masayoshi NAKOJI,Yuichi TAKAHASHI,Yasuo KOUDA

申请号：

US15123438

公开号：

US20170354673A1

申请日:

2015.03.03

申请国别(地区):

US

年份:

2017

代理人:

摘要：

An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5′ end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.

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