Oligonucleotide having non-natural nucleotide at 5-terminal thereof农业专利-农业学术服务平台

发明人:: SHINOHARA, FUMIKAZU,筱原史一,篠原史一,MAKINO, ASANA,牧野麻奈,牧野麻奈,YAMAMOTO, JUNICHIRO,山本润一郎,山本潤一郎,NAKAJIMA, TAKAHIRO,中岛雄大,中島雄大,OASHI, TAIJI,小苇泰治,小葦泰治,SUZUKI, MICHIHIKO,铃木道彦,鈴木道彦,SAITO, JUN-ICHI,斋藤纯一,齋藤純一,NISHIKAW

摘要：: Provided are: an oligonucleotide having, at 5-terminal thereof, a nucleotide or nucleoside residue represented by formula (I) {wherein X1 represents an oxygen atom or the like R1 represents formula (IIA) (wherein R5A represents a halogen atom or the like and R6A represents a hydrogen atom or the like), formula (IVA) (wherein Y3A represents a nitrogen atom or the like and Y4A represents CH or the like) or the like R2 represents a hydrogen atom, a hydroxy group, a halogen atom or a lower alkoxy group which may have a substituent and R3 represents a hydrogen atom or formula (VI) (wherein n2 represents 1, 2 or 3)}, wherein the nucleotide or nucleoside residue is bound to an adjacent nucleotide residue through an oxygen atom that is located at position-3 in the nucleotide or nucleoside residue and others.本發明提供一種寡核苷酸等,其於寡核苷酸之5末端具有式(I)所表示之核苷酸殘基或核苷殘基,該核苷酸殘基或核苷殘基經由3位之氧原子而與鄰接之核苷酸殘基鍵結,(式中,X1為氧原子等,R1為式(IIA)(式中,R5A為鹵素等,R6A為氫原子等)、式(IVA)(式中,Y3A為氮原子等,Y4A為CH等)等,R2為氫原子、羥基、鹵素或可具有取代基之低級烷氧基,R3為氫原子或(式中,n2為1、2或3)}。