The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided comprising 10 or more capsular saccharides from different S. pneumoniae serotypes which are conjugated to a carrier protein, and comprising 3 or more different carrier proteins, wherein the composition comprises: serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT)； serotype 18C capsular saccharide conjugated to tetanus toxoid (TT)； serotype 1,4,5,6B,7F,9V,14 and 23F capsular saccharides conjugated to protein D from Haemophilus influenzae .本發明係關於肺炎球菌莢膜醣結合物疫苗領域。詳言之，本發明提供一種嬰兒用免疫原組合物，其包含多價肺炎鏈球菌疫苗，該多價肺炎鏈球菌疫苗包括2種或2種以上得自不同血清型之莢膜醣結合物，其中該組合物包含血清型22F醣結合物。該疫苗可用於嬰兒人口群或老年人口群，以降低諸如慢性阻塞性肺疾病(COPD)惡化及/或侵入性肺炎球菌疾病(IPD)等肺炎球菌疾病之發病率。
