SIKORA, ANDREW G.,PATHAK, RAVI,SAN MARTIN, REBECA,ROWLEY, DAVID R.
申请号：
CA3035233
公开号：
CA3035233A1
申请日:
2017.08.24
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Embodiments of the present disclosure concern systems, methods, and compositions for both in vitro and in vivo models of metastases, such as bone metastases. In specific embodiments, there is a system comprising a source of bone cells, such as osteoblasts, and a source of cancer cells, wherein the bone cells and cancer cells are configured in a chamber or on a chick chorioallantoic membrane such that interaction between the cells is determined. In specific embodiments, the bone cells are comprised in an organoid comprising both mesenchymal stem cells and osteoblasts (although a naturally derived bone scaffold may be employed), and the cancer cells are comprised in an organoid comprising mesenchymal stem cells and the cancer cells.
