SIKORA, Andrew G.,PATHAK, Ravi,SAN MARTIN, Rebeca,ROWLEY, David R.
申请号:
EP17847249
公开号:
EP3503902A4
申请日:
2017.08.24
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Embodiments of the present disclosure concern systems, methods, and compositions for both in vitro and in vivo models of metastases, such as bone metastases. In specific embodiments, there is a system comprising a source of bone cells, such as osteoblasts, and a source of cancer cells, wherein the bone cells and cancer cells are configured in a chamber or on a chick chorioallantoic membrane such that interaction between the cells is determined. In specific embodiments, the bone cells are comprised in an organoid comprising both mesenchymal stem cells and osteoblasts (although a naturally derived bone scaffold may be employed), and the cancer cells are comprised in an organoid comprising mesenchymal stem cells and the cancer cells.