Méthodes d'induction de la différenciation de cellules de mammifère non différentiées en ostéoblastes

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专利权人:

Galapagos N.V.

发明人:

申请号：

EP10174533.9

公开号：

EP2248896A3

申请日:

2004.12.29

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention provides methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts, and methods for identifying a compound that induces differentiation of undifferentiated mammalian cells into osteoblasts. In addition, the present invention provides polynucleotides and vectors, and the use thereof as a medicament for the treatment of a disease involving a systemic or local decrease in mean bone density. Moreover, the present invention provides methods for in vitro production of bone tissue, osteoblast cells and methods for diagnosing a pathological condition involving a systemic or local decrease in mean bone density or a susceptibility to the condition.

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