AMBLARD, Franck,弗蘭克.安布拉爾,COATS, Steven, J. J,斯蒂文.,SCHINAZI, Raymond, F. F,.科阿斯,雷蒙德.,.斯基那茲
申请号：
HK16102408.4
公开号：
HK1214270A
申请日:
2016.03.02
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengue virus, Yellow fever, or HBV in human patients or other animal hosts. The compounds are certain N4-hydroxycytidine nucleosides derivatives, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengue virus, Yellow fever, and HBV.
