The present invention relates to 2-Fluoro-6-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses.本發明有關2’-氟-6’-亞甲基碳環核苷類、含該等核苷類之醫藥組成物及彼等於治療或預防許多病毒感染及其續發性疾病狀態及病況(特別包括B型肝炎病毒(HBV)及其續發性疾病狀態及病況(硬化及肝癌)、C型肝炎病毒(HCV)、單純疱疹病毒I及II(HSV-1及HSV-2)、細胞巨大病毒(CMV)、水痘帶狀皰狀病毒(VZV)及艾伯斯坦-巴爾病毒(Epstein-Barr virus,EBV)及彼等所發生之續發性癌症(淋巴瘤、鼻咽癌,包括抗藥性(特別是包括拉米呋啶及/或阿德福韋抗性)及該等病毒之其他突變形式)之用途。
