Pyrimidine nucleotides and their monophosphate prodrugs for treatment of viral infections and cancer

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专利权人:

发明人:

AMBLARD FRANCK,COATS STEVEN J,SCHINAZI RAYMOND F

申请号：

IN4458/DELNP/2015

公开号：

IN2015DN04458A

申请日:

2015.05.25

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The present invention is directed to compounds compositions and methods for treating or preventing cancer and viral infections in particular HIV HCV Norovirus Saporovirus cytomegalovirus (CMV) herpes viruses (HSV 1 HSV 2) Dengue virus Yellow fever or HBV in human patients or other animal hosts. The compounds are certain A^ hydroxycytidine nucleosides derivatives modified monophosphate and phosphonates prodrugs analogs and pharmaceutically acceptable salts prodrugs and other derivatives thereof. In particular the compounds show potent antiviral activity against HIV 1 HIV 2 HCV Norovirus Saporovirus cytomegalovirus (CMV) herpes viruses (HSV 1 HSV 2) Dengue virus Yellow fever and HBV.

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中国工程科技知识中心

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