Approximately, content of the lactose particle which possesses the cubic measure mean diameter of 70 microns or less 10% (w/w) offers plural lactose particles which are below Pulverizing above-mentioned plural lactose particles, mean diameter of the range of approximately 50 microns - approximately 100 microns (D50) the plural which it possesses make the lactose particle form where is pulverized And, two which includes fine grain amount and grain amount fractions (here, fine grain amount mean diameter of the range of approximately 3 microns - approximately 50 microns (D50) has the lactose particle where the above-mentioned plural is pulverized, at least, the method of making the lactose form to which grain amount mean diameter of the range of approximately 40 microns - approximately 250 microns (D50) possesses) includes the fact that the classification it does, is suited for the use with the medicine formulation.約70ミクロン以下の体積平均粒径を有する乳糖粒子の含有量が10%(w/w)以下である複数個の乳糖粒子を提供すること;上記複数個の乳糖粒子を粉砕して、約50ミクロン~約100ミクロンの範囲の平均粒径(D50)を有する複数個の粉砕された乳糖粒子を生成させること;及び、上記複数個の粉砕された乳糖粒子を、細粒分と粗粒分を含む少なくとも2つの画分(ここで、細粒分は、約3ミクロン~約50ミクロンの範囲の平均粒径(D50)を有し、粗粒分は、約40ミクロン~約250ミクロンの範囲の平均粒径(D50)を有する)に分級することを含む、医薬製剤での使用に適する乳糖を形成させる方法。
