COATE, Heather R.,DVORAK, Curt A.,FITZGERALD, Anne E.,LEBOLD, Terry P.,PREVILLE, Cathy,SHIREMAN, Brock T.
申请号：
ES14717297
公开号：
ES2659222T3
申请日:
2014.03.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I: ** Formula ** or an enantiomer or diastereomer, tautomer or isotopic variant thereof； or a pharmaceutically acceptable salt or solvate thereof； where ring A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl or indazolyl； R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl or dialkylamino, where phenylazole, where phenylene oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl or morpholinyl are optionally substituted with up to two substituents selected from the group consisting of halo and alkyl； R2 is H, alkyl, alkoxy, hydroxyalkylene or halo； Z is NH, N-alkyl or O； R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl, thiazolyl, thiadiazolyl, benzoxazolyl, imidazopyrazinyl or triazolopyrazinyl, optionally substituted with one or two substituents independently selected from the group consisting of alkoxy, cyano alkoxy, cyano ； and n is 0 or 1, where "alkyl" is a straight or branched chain alkyl group having 1 to 12 carbon atoms in the chain or a monocyclic non-aromatic hydrocarbon group having 3 to 7 carbon atoms and is optionally substituted with one or more halogen atoms.Un compuesto de fórmula I: **Fórmula** o un enantiómero o diastereómero, tautómero o variante isotópica del mismo； o una sal o solvato farmacéuticamente aceptable del mismo； donde el anillo A es fenilo, naftalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tiazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo o indazolilo； R1 es H, alquilo, alcoxi, hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazolilo, piridilo, pirimidinilo, pirazinilo, pirida
