COLLETTI, Steven L.,TUCKER, Thomas J.,TELLERS, David M.,KIM, Boyoung,BURKE, Rob,CALATI, Kathleen B.,STANTON, Matthew G.,PARMAR, Rubina G.,AARONSON, Jeffrey G.,WANG, Weimin
申请号：
EP14860042
公开号：
EP3065758A4
申请日:
2014.11.03
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Disclosed herein is a peptide containing conjugate comprising (P)c-(L)d-(G)e, wherein P is a peptide and each occurance of P is independently selected from Table 2 L is an optional linker and each occurance of L, if present, is independently selected from Table 3 G is a targeting ligand and each occurance of G is independently selected from Table 4 d is 0, 1, 2, 3, 4, 5 or 6 and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)a-(G)b, wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.
