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CONJUGUÉS CONTENANT DES PEPTIDES POUR DOUBLE DISTRIBUTION MOLÉCULAIRE D'OLIGONUCLÉOTIDES
专利权人:
TELLERS, David, M.;WANG, Weimin;PARMAR, Rubina;MERCK SHARP & DOHME CORP.;TUCKER, Thomas, J.;STANTON, Matthew, G.;AARONSON, Jeffrey, G.;COLLETTI, Steven, L.;BURKE, Rob;CALATI, Kathleen, B.;KIM, Boyoung
发明人:
AARONSON, Jeffrey, G.,WANG, Weimin,COLLETTI, Steven, L.,TUCKER, Thomas, J.,TELLERS, David, M.,KIM, Boyoung,BURKE, Rob,CALATI, Kathleen, B.,STANTON, Matthew, G.,PARMAR, Rubina, G.
申请号:
USUS2014/063624
公开号:
WO2015/069587A9
申请日:
2014.11.03
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed herein is a peptide containing conjugate comprising (P)c-(L)d-(G)e, wherein P is a peptide and each occurance of P is independently selected from Table 2; L is an optional linker and each occurance of L, if present, is independently selected from Table 3; G is a targeting ligand and each occurance of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)a-(G)b, wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.
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