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CONJUGUÉS CONTENANT DES PEPTIDES POUR DOUBLE DISTRIBUTION MOLÉCULAIRE D'OLIGONUCLÉOTIDES
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
EP19195228.2
公开号:
EP3610884A1
申请日:
2014.11.03
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Disclosed herein is a peptide containing conjugate comprising (P)c-(L)d-(G)e, wherein:P is a peptide having Seq ID No. 1710; L is a linker and each occurance of L is independently selected from Table 3; G is a targeting ligand and each occurance of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)a-(G)b, wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.
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中国工程科技知识中心
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