Preparation of sustained Release comprising Pioglitazone or salt; Preparation method; use to prevent or delay the onset and / or suppress the progression of Alzheimer's disease.
Provided is a sustained-release preparation containing pioglitazone or a salt thereof as an active ingredient and showing superior sustainability. A sustained-release preparation containing pioglitazone or a salt thereof, which shows a dissolution ratio of pioglitazone of average 25-58% at the 2-hour time point, and average 60-100% at the 4-hour time point, in a dissolution test according to the 50 rpm USP Paddle Method and using pH 2.0 KCl/HCl buffer at 37° C. as a test solution.<;p>;La solicitud 201400992 describe a una composició;n farmacé;utica de liberació;n sostenida que comprende pioglitazona o una sal de é;sta, un polí;mero formador de gel y un promotor formador de gel; el procedimiento de preparació;n de la composició;n de liberació;n sostenida, y el uso de la composició;n de liberació;n sostenida para preparar un medicamento para prevenir o retardar el inicio o suprimir la progresió;n de la enfermedad de Alzheimer.<;/p>;