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专利权人:
IOMET PHARMA LTD.
发明人:
Phillip COWLEY,Alan WISE,Susan DAVIS,Michael KICZUN
申请号:
MX2016012984
公开号:
MX2016012984A
申请日:
2015.03.19
申请国别(地区):
MX
年份:
2017
代理人:
摘要:
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the following formula: wherein X1, X2, X3, X4, and X5 may be the same or different and each is independently selected from C, N and O each atom having a dotted line may independently have a double bond or a single bond, provided that valencies at each atom are maintained each R1, R2, R3, R4, R5, and R7 may be present or absent and may be the same or different and is selected from H and a substituted or unsubstituted organic group, provided that the number of such R groups present is such that the valencies of X1, X2, X3, X4, and X5 are maintained one or two R6 groups may be present and are selected from H and a substituted or unsubstituted organic group, provided that the number of R6 groups present is such that the valency of the carbon atom to which they are attached is maintained, and provided that at least one R6 is an organic group comprising an atom double-bonded to an oxygen atom (preferably a carbonyl group or a sulphonyl group) at an a-, ß-, or ?-position to the carbon atom to which the R6 is attached and in which the atom double-bonded to an oxygen atom is also bonded to a hetero-atom.Se provee un compuesto inhibidor de triptófano-2,3-dioxígenasa (TDO) y/o de indolamina-2,3-dioxigenasa (IDO) para su uso en medicamentos, cuyo compuesto comprende la siguiente fórmula: (ver Fórmula) en donde X1, X2, X3, X4 y X5 pueden ser el mismo o diferente y cada uno está independientemente seleccionado de C, N y O cada átomo tiene una línea punteada que puede tener, independientemente, un doble enlace o un enlace sencillo, siempre y cuando se mantengan las valencias en cada átomo cada R1, R2, R3, R4, R5 y R7 puede estar presente o ausente y puede ser el mismo o diferente y se seleccionan de H y un grupo orgánico sustituido o no sustituido siempre y cuando el número de tales grupos R presentes sea tal que se mantengan las
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