Konstantin Valentinovich Gaidul;Viktor Lvovich Limonov;Aleksandr Valerevich Dushkin
发明人:
Viktor Lvovich Limonov,Konstantin Valentinovich Gaidul,Aleksandr Valerevich Dushkin
申请号：
US13389533
公开号：
US20130164336A1
申请日:
2011.05.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
There is proposed herein a process for production of composite antimicrobial preparations for parenteral administration, featuring a higher therapeutic efficiency in case of grave infection and inflammatory diseases. The proposed compositions include an active agent being fosfomycin and finely dispersed nanostructured silica dioxide, with a weight ratio from 10:1 to 75:1 respectively. The mentioned production process includes mixing fosfomycin with finely dispersed nanostructured silica dioxide. Its main difference is that the mixture of aforementioned substances with the mentioned weight ratio is exposed to mechanical processing by blow impact and abrasive actions until a portion of the fine powder fraction with particles smaller than 5 micrometers, contained in the mixture, increases to at least 25%. The so obtained mixture is used for injection preparations.
