RECEPTOR-MEDIATED UPTAKE OF PEPTIDES THAT BIND THE HUMAN TRANSFERRIN RECEPTOR

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专利权人:

UAB RESEARCH FOUNDATION

发明人:

ENGLER, JEFFREY,LEE, JAE, HWY,COLLAWAN, JAMES,MOORE, BRYAN

申请号：

CA2449412

公开号：

CA2449412C

申请日:

2001.11.29

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

Peptides have been discovered which are capable of binding to andinternalizing with the human transferrin receptor (hTfR). The sequencesHAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable ofbinding to and internalizing with the human transferrin receptor. When thesemolecules were fused with other molecules, the fusion product was internalizedin cells expressing hTfR. The sequences have use for targeting other peptidesand proteins into cells expressing hTfR.

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