Claire Ashman;Mary Birchler;Rudolf M. T. De Wildt;Claire Holland;Alan Peter Lewis;Peter Morley;Thomas Sandal;Michael Steward
发明人:
Claire Ashman,Mary Birchler,Rudolf M. T. De Wildt,Claire Holland,Alan Peter Lewis,Peter Morley,Thomas Sandal,Michael Steward
申请号：
US14239196
公开号：
US10808040B2
申请日:
2012.08.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.
