UNIVERSITY OF ROCHESTER;BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人:
GELBARD, HARRIS A.,DEWHURST, STEPHEN,GENDELMAN, HOWARD E.
申请号：
EP13857739
公开号：
EP2925319A4
申请日:
2013.11.30
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed.
