UNIVERSITY OF ROCHESTER;BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人:
Harris A. Gelbard,Stephen Dewhurst,Howard E. Gendelman
申请号：
US14648404
公开号：
US20150297587A1
申请日:
2013.11.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed.
