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Piperidinilo Derivatives, a process for their Preparation and Pharmaceutical compositions containing them
专利权人:
LES LABORATOIRES SERVIER;VERNALIS (R&D) LTD.
发明人:
DEMARLES, DIDIER,CHANRION, MAA,GENESTE, OLIVIER,LEWKOWICZ, ELODIE,MURRAY, JAMES BROOKE,MACIAS, ALBA,KISS, RPD,MOLNR, BALZ,VASAS, ATTILA,WBER, CSABA,KOTSCHY, ANDRS
申请号:
ARP170101587
公开号:
AR108706A1
申请日:
2017.06.09
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Claim 1: consists of formula (1),where: R¹ represents an aryl group or a heteroaryl group; R² represents a hydrogen atom or a halogen atom; R³ represents a hydrogen atom, a linear or branched C₁₋₆ alkyl group, a linear or branched C₁₋₆ haloalkyl, a -C (O) -R⁸ group,un grupo -C (O) -ORN integer equals 0, 1 or 2; W represents formula group (2),wherein: A represents a heteroaryl ring; X represents a carbon atom or a nitrogen atom; R⁴ represents a hydrogen atom, a halogen atom, a linear or branched C₁₋₆ alkyl group, a linear or branched C₂₋₆ alkenyl group, a linear or branched C₂₋₆ alkynyl group, a -Y¹-NR⁶R⁷ group,One group - y1-or8310,A halogeo group c83216c831832626 linear or branch, oxo group, UN group-y1-c1,One group - cy1-r8311;One group - cy1-or8311;O one group - y1-nr8310c (o) - r8311;R⁵ represents a hydrogen atom, a halogen atom, a linear or branched C₁₋₆ alkyl group, a cyano group, or a C₁₋₆ -hydroxyalkyl group;R⁶ represents a hydrogen atom or a linear or branched C₁₋₆ alkyl group, or a -Y²-Si [C₁₋₄ alkyl] grupo group;R⁷ represents a hydrogen atom, a linear or branched C₁₋₆ alkyl group, or a -Y²-Cy² group;Y¹ and Y² independently of one another represent a bond or a linear or branched C₁₋₄ alkylene group; R⁸ represents a hydrogen atom, or a linear or branched C₁₋₆ alkyl group; Cy¹ and Cy² independently of one another represent a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; with the understanding that: "aryl" means a phenyl, naphthyl, or indanyl group; "Heteroaryl" means any fused monocyclic or bicyclic group consisting of 5 to 10 ring members, having at least one aromatic moiety and containing 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen;"Cycloalkyl" means any fused monocyclic or bicyclic non-aromatic carbocyclic group containing 3 to 7 ring members; "Heterocycloalkyl" means any fused monocyclic or bicyclic non-aromatic group containing from 3 to 10 ring members, and containing from 1 to 3 heteroatoms selected
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