您的位置: 首页 > 农业专利 > 详情页

THERMOSENSITIVE COMPOSITIONS IN THE TYPE OF NANOPARTICLES AND METHOD FOR PRODUCING THEM
专利权人:
СЕЛШН КОРПОРЕЙШН (US)
发明人:
РИД Роберт А. (US),СУ Дайшуй (US)
申请号:
RU2014133467
公开号:
RU2014133467A
申请日:
2013.02.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A liposome preparation containing a suspension of liposomes containing a gel lipid bilayer and an active agent enclosed within liposomes, wherein said lipid bilayer contains: (i) one or more phospholipids selected from the group consisting of phosphatidylcholines, phosphatidylglycerols, phosphatidylinositols and phosphatidylinositols; ii) one or more phospholipids derivatized with a hydrophilic polymer; and (iii) one or more lysolipids selected from the group consisting of monoacylphosphatidylglycerols, monoacylphosphatidylglycerols, monoacylphosphatidylinositols, monoacylphosphatidyl ethanolamines, wherein the active agent is selected from the group consisting of doxacorubinodinocin dicarubin dicarubicin dicarubicin dicarubicin dicarubicin dicarubicin dicarubin azin , mitomycin, mitoxantrone, vinblastine, vinorelbine and vincristine, and wherein the components of the lipid bilayer are represented in a molar ratio of about 80-90: 2-8: 2-18; and wherein the liposomes in suspension have a size of from about 50 to about 150 nm. 2. The liposome preparation according to claim 1, characterized in that the active agent is doxorubicin, the relative concentration of impurity A after 6 months of storage at a temperature of less than or equal to 8 ° C is less than 0.5%, and impurity A forms a peak with relative a retention time of about 1.4 when analyzed by high performance liquid chromatography (HPLC) on a C18 column with a reversed phase when eluting with a gradient of acetic acid / methanol. 3. A liposome preparation according to claim 2, characterized in that the relative concentration of impurity A after 6 months of storage at a temperature of less than or equal to 8 ° C is less than 0.2%. 4. The liposome preparation according to claim 2, characterized1. Липосомный препарат, содержащий суспензию липосом, содержащих гелевый липидный бислой и активный агент, заключенный внутри липосом, где указанный липидный бислой содержит:(i) один или более фосфолипид, выбранный из гру
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充