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СПОСОБЫ ОБРАБОТКИ ИМПЛАНТАТОВ ДЛЯ ТЕРМИЧЕСКИ НЕУСТОЙЧИВЫХ И ДРУГИХ БИОЛОГИЧЕСКИ АКТИВНЫХ АГЕНТОВ И ПОЛУЧЕННЫЕ ИЗ НИХ ИМПЛАНТАТЫ
专利权人:
ЭВОНИК ДЕГУССА КОРПОРЭЙШН (US)
发明人:
МАРКЛЭНД Питер (US),ТАЙС Томас Р. (US)
申请号:
RU2013103740/15
公开号:
RU2013103740A
申请日:
2011.06.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of producing an implant comprising (a) mixing a composition comprising a bioresorbable polymer and a biologically active agent to form a mixture and (b) processing the mixture into the implant at a temperature not exceeding 70 ° C.2. A method according to claim 1, wherein step (a) is conducted at a temperature of 65 ° C or nizhe.3. The method of claim 1, wherein forming the mixture of step (a) comprises spraying or applying a layer of a solution of a biologically active agent to polimer.4 bioresorbable. A method according to claim 1, wherein step (a) is conducted at a temperature of 25 ° C or less.5. A method according to claim 1, wherein step (b) is conducted at a temperature of 25 ° C or nizhe.6. A method according to claim 1, wherein step (b) comprises extruding the mixture under pressure using a tableting mashiny.7. A method according to claim 1, wherein prior to or during step (b) bioresorbable polymer is contacted with a liquid, gaseous or polymeric plasticizing agentom.8. A method according to claim 1, wherein the bioresorbable polymer is a poly (lactide), poly (glycolide), poly (caprolactone), poly (lactide-co-glycolide) or a copolymer thereof, or combination smes.9. A method of producing an implant comprising (a) mixing at room temperature or below bioresorbable polymer with a biologically active agent to form a mixture and (b) extruding the mixture under pressure at room temperature or nizhe.10. A method according to claim 9, wherein before or after step (a) polymer is contacted with a liquid, gaseous or polymeric plasticizing agentom.11. A method according to claim 10, wherein the plasticizing agent comprises an organic rastvoritel.12. A method of producing an implant comprising (a) cooling the bioresorbable polymer at -150 ° C or below (B) grinding biorezor1. Способ получения имплантата, включающий (а) смешивание композиции, содержащей биорезорбируемый полимер и биологически активный агент, с получением смеси и (b) обработка смеси в имплантат
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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