DERIVES DE LA FUSION PYRROLIDINO-CYCLOPROPANE UTILISES COMME INHIBITEURS SELECTIFS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1

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专利权人:

MERCK PATENT GMBH

发明人:

VALEUR, ERIC,LEPIFRE, FRANCK,ROCHE, DIDIER,CARNIATO, DENIS,CHRISTMANN-FRANCK, SERGE,SCHMIDLIN, FABIEN

申请号：

CA2735286

公开号：

CA2735286C

申请日:

2009.08.05

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to fused pyrrolidino-cyclopropane derivativesaccording to Formulae (I) to (II), as selectiveinhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1(11-.beta.-HSD-1 ) and the use of such compounds forthe treatment and/or prevention of metabolic syndrome, diabetes, insulinresistance, obesity, lipid disorders, glaucoma,osteoporosis/ cognitive disorders, anxiety, depression, immune disorders,hypertension and other diseases and conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/