Stable polypeptides binding to human complement C5

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专利权人:

Swedish Orphan Biovitrum AB (publ)

发明人:

Joakim Nilsson,Erik Nordling,Patrik Strömberg

申请号：

US14914290

公开号：

US09994626B2

申请日:

2014.08.28

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The invention relates to a polypeptide capable of binding human complement component 5 (C5), said polypeptide comprising the amino acid sequence(SEQ ID NO: 296)[BM]-[L2]-QSX42X43LLX46EAKKLX52X53X54Qwherein [BM] is a C5 binding motif； [L2] is an interconnecting loop； X42 is selected from A and S； X43 is selected from N and E； X46 is selected from A, S and C； X52 is selected from E, N and S； X53 is selected from D, E and S, provided that X53 is not D when X52 is N； and X54 is selected from A and S.

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