Sookhee Bang,Jeong Kuen Song,Seung-Wook Shin,Kwan Hee Lee,Ho June Lee
申请号：
US16556957
公开号：
US20200230218A1
申请日:
2019.08.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present application discloses a method for treating a protein deficiency in the central nervous system of a subject in need thereof, comprising systemically administering to the subject a therapeutically effective dose of a fusion polypeptide comprising the first protein, wherein the fusion polypeptide comprises: (a) the first protein； (b) a second protein that provides extended circulation-lifetime in vivo and (c) blood brain barrier crossing facilitating peptide； wherein the fusion polypeptide crosses the blood brain barrier (BBB).
