Tao Yu,Kannie W. Y. Chan,Ming Yang,Michael T. McMahon,Justin Hanes
申请号：
US15509061
公开号：
US20170281541A1
申请日:
2015.09.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Liposome-based mucus-penetrating particles (MPP) capable of loading hydrophilic agents including therapeutic, prophylactic and diagnostic agents such as the diaCEST MRI contrast agent barbituric acid (BA) were evaluated to determine how to optimize delivery. Polyethylene glycol (PEG)-coated liposomes containing ≧7 mol % PEG diffused only approximately 10-fold slower in human cervicovaginal mucus (CVM) compared to their theoretical speeds in water. 7 mol %-PEG liposomes provided improved vaginal distribution compared to 0 and 3 mol %-PEG liposomes.
