Ahmet GÛN,Banu Öztuna,Bayram Kanik,Ediz AKZOY,Levent ÜNVER,Levent ÖNER
申请号：
US15735607
公开号：
US20180311201A1
申请日:
2015.06.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition for oral use comprising therapeutically effective amount of otilonium bromide in combination with therapeutically effective amount of simethicone, wherein the composition possesses certain bulk density and improved dissolution characteristics. Wherein a final blend prior to compression has a bulk density of at least 0.35 g/mL, and at least 85% of the otilonium bromide is released in 15 minutes in each of 0.1 N HCl, pH 4.5 and pH 6.8 buffer solutions at 37±0.5° C. using USP type II (paddle) apparatus rotating at 50 rpm.
