KIM, HYE SUN,김혜선,JANG, MUN JU,장문주,CHUNG, HYUNG MIN,정형민
申请号：
KR1020110016103
公开号：
KR1020120096793A
申请日:
2011.02.23
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A composition for immunological reaction suppression including placenta originated stem cells is provided to be used for an acute or chronic Graft Versus Host Disease therapeutic agent.CONSTITUTION: A composition for immunological reaction suppression includes placenta originated stem cell as an active ingredient. The mesenchyme stem cell is originated from chorionic plate film of placenta. The mesenchyme stem cell expresses CD105, CD44, CD73 or CD90 cell surface antigens which are lobus medius indicators. The composition induces reduction of S phase and G2/M(mitotic) phase and increase of cell cycle G0/G1 phase of lymphocyte cell. The composition reduces CD69+ cell. The composition suppresses immune reaction for the transplanted organs or cells. The transplanted organs or cells are isotransplant or xenograft. The composition is used for treatment or prevention of autoimmune diseases or rejection of internal organ transplant reaction. The autoimmune disease is GVHD(graft-versus-host disease). The composition is manufactured in the injection form.COPYRIGHT KIPO 2012본 발명은 태반유래 중간엽 줄기세포를 유효성분으로 포함하는 면역반응 억제용 조성물에 관한 것이다. 또한, 본 발명은 상기 조성물을 치료적 유효량으로 개체에 투여하는 단계를 포함하는 면역 반응 억제 방법에 관한 것이다. 본 발명은 태반 융모판막유래 중간엽 줄기세포를 이용한 급성 또는 만성 이식편대숙주질환 치료제로 이용할 수 있으며, 조혈모 세포 이식수술 후 자주 발생하고 있는 이식편대숙주질환을 효과적으로 치료할 수 있다.
