BROECKX, Rudy Laurent Maria,FILLIERS, Walter Ferdinand Maria,NIESTE, Patrick Hubert J,COPMANS, Alex Herman,VANHOUTTE, Filip Marcel C,LEYS, Carina
申请号:
LT13711105
公开号:
LT2834244T
申请日:
2013.03.13
申请国别(地区):
LT
年份:
2016
代理人:
摘要:
There is provided inter alia a dry powder pharmaceutical formulation for inhalation comprising: (i) 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof and solvates thereof in particulate form as active ingredient; (ii) particulate lactose as carrier; and (iii) a particulate stabilizing agent selected from metal salts of stearic acid such as magnesium stearate and metal salts of stearyl fumarate.