LENNOX, JOSEPH R.,XIANG, ALAN XIN,WEBBER, STEPHEN E.,HALEY, GREGORY J.
申请号：
CA2655904
公开号：
CA2655904C
申请日:
2007.06.21
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention relates to a compound of Formula I:(see formula I)or a pharmaceutically acceptable salt thereof, wherein: R1 is NH2 or -N=CH-NR6R7, R2 is H,OH, or -OR5, R3 is OH, -OC(O)C1-C18alkyl, -OCO2R5, -OC(O)NR6R7, or a racemic,L-, orD-amino acid group -OC(O)CHR8NHR9, R4 is OH, -OC(O)C1-C18alkyl, -OCO2R5,-OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, R5 is-C1-C7alkyl, R6 and R7 are independently -C1-C7alkyl or together with nitrogenatom to whichthey are attached form a 5- or 6-membered heterocyclic ring, R8 is H or -C1-C7alkyl, R9 is H,-C1-C7alkyl, -C(O)R5, or -CO2R5, wherein at least one of R3 or R4 is -OCO2R5,-OC(O)NR6R7, or a racemic, L-, or D-amino acid group -OC(O)CHR8NHR9, andwherein theabove alkyl is optionally substituted by 1-4 substituents. The invention alsorelates to thetherapeutic use of such a compound and pharmaceutical compositions thereof formodulatingimmune cytokine activities and in treating disease states associated withabnormal cellgrowth, such as cancer.
