Oxvig, Claus,Nielsen, Claus Gyrup,Mikkelsen, Jakob Hauge
申请号：
AU2009207645
公开号：
AU2009207645B2
申请日:
2009.01.23
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.
